The Bavarians, unbeaten now in 32 consecutive matches, also won the domestic league and Cup double as well as the Champions League after Flick took over last November. Their last defeat dates back to December, 2019.
Portugal international Goncalo Guedes fired Valencia into the lead in the 35th minute with a thumping shot from inside the area which was too powerful for Madrid goalkeeper Keylor Navas.
The 39-year-old appeared at Italy's Sanremo festival in March, where he sang a duet with Bologna coach Sinisa Mihajlovic and said he would like to try acting.
Sevilla, winners of the Europa League for the past two years, will play Shakhtar Donetsk in this season's semi-final.
'It wasn't easy, but I called him last night (Sunday) and we had a difficult and tough conversation. I feel bad as he's a player who has always been at the top level and has a future with the national team.'
'I want the market to damn well close so that I know who I can count on'
Federico Valverde finished off a stunning move in extra time to give Real Madrid a 3-2 victory over arch-rivals Barcelona
Atletico Madrid surrendered top spot in La Liga to Barcelona when they were held to a 0-0 draw at home to 10-man Sevilla in a fiercely contested La Liga clash on Sunday.
The Portugal forward will miss Real's league games against Villarreal, Getafe and Elche but will be available for the King's Cup semi-final, first leg at home to holders Atletico Madrid later on Wednesday and the return game next week.
A magical Lionel Messi goal, the first of a personal double, led treble-chasing Barcelona to a 3-1 victory over Athletic Bilbao in the King's Cup final on Saturday.
With the Catalans shorn of three of their top forwards, all eyes will be on Griezmann in his first appearance at the Camp Nou since his 120-million-euro ($133 million) move from Atletico Madrid, and not least because Barca need a win to kickstart their season.
Atletico Madrid moved a step closer to an unlikely Spanish title triumph when they battled back from a goal down to secure a 2-1 win at fourth-placed Athletic Bilbao in La Liga on Saturday.
Chelsea have signed Spanish goalkeeper Kepa Arrizabalaga for a world record 80 million-euro ($92.8 million) fee from Athletic Bilbao, the Premier League club said on Wednesday.
Barcelona suffered their first league defeat of the season when they went down 1-0 at Athletic Bilbao while Arsenal stayed clear at the head of the Premier League.
Manchester Utd's Fred receives racist abuse after defeat by Liverpool.
The league, which is now conducting tests twice per week, did not name the people who tested positive but said they will self-isolate for 10 days.
UEFA president Aleksander Ceferin said he expected matches to be played without fans, although there was a small chance that could change.
Images from the soccer matches played across Europe on Saturday.
Atletico Madrid maintained a two-point lead in La Liga with a 3-0 victory at Las Palmas and Barcelona and Real Madrid stayed hard on their heels with thumping wins over Athletic Bilbao and Sporting Gijon on Sunday.
Zlatan Ibrahimovic pulled up at the end of the session, possibly with a calf muscle problem. Atletico Madrid's record signing Joao Felix is likely to miss the start of the Spanish soccer season when it resumes next month after sustaining a sprained knee in training.
Zidane will come up against Guardiola for the first time as a manager when their sides meet in a blockbuster tie in the Champions League last 16 next February.
Real Madrid forward Karim Benzema kept up his impressive run of form by scoring and providing two assists in a 3-1 win away to Eibar on Sunday, taking the champions level on points with La Liga leaders Atletico Madrid.
IMAGES from football matches played in the Spain, Germany and Portugal on Wednesday.
Cristiano Ronaldo's teammates have issued a strong defence of his value to Real Madrid as the Portuguese striker grapples with a barren streak that has sparked a debate about his place in the team.
Two goals by the dynamic Lionel Messi helped La Liga leaders Barcelona maintain their flying start to the season with a 5-1 destruction of Athletic Bilbao.
The Manchester clubs' wretched continental seasons ended on Thursday as outclassed United and battling City suffered contrasting Europa League last-16 exits to an exhilarating Athletic Bilbao and a fortunate Sporting respectively.
Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
Manchester United and Liverpool, English football's two most decorated clubs, were drawn together in the last 16 of the Europa League on Friday.
Red Star, who won the European Cup in 1991 and reached the latter stages the following season, finished second in Group H behind Arsenal who crushed BATE Borisov 6-0.
Levante continued to defy their humble status as Valencia's second club when they beat Real Betis 3-1 to reclaim fourth place in La Liga on Monday.
Lionel Messi was lauded by opposition supporters on Sunday after he scored an outstanding hat-trick in Barcelona's 4-1 win at Real Betis, which put the Catalans 10 points clear at the top of La Liga with 10 games remaining.
The win took Barca to the top of the standings on 68 points although Real Madrid, on 65, will reclaim their lead due to their superior head-to-head record if they beat Real Mallorca at home on Wednesday.
The injury list in the La Liga keeps growing as the season progresses and this time Lionel Messi and Gareth Bale are the unfortunate victims...
News of all that transpired on and off the football field.
Fellow Spaniards at Chelsea convinced me to join club, says Kepa
Atletico coach Simeone defends VAR for making football fairer
Spain and Portugal played out an entertaining 0-0 draw on Friday as both sides prepared for this month's European Championship.
Premier League-based trio Diego Costa, Juan Mata and Santi Cazorla were among a high-profile list of absentees when Spain coach Vicente Del Bosque named his provisional 25-man squad for Euro 2016 on Tuesday. Costa injured his hamstring against Liverpool in Chelsea's penultimate game of the season. Atletico Madrid striker Fernando Torres was also absent from the squad despite his improved form towards the end of the season, as were Arsenal midfielder Cazorla and Valencia forward Paco Alcacer, Spain's top scorer in their qualifying campaign.
Barcelona defender Gerard Pique blamed the club's pre-season trips to the United States and Japan for their shaky start to the season.